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Basic insulin can't be tweaked, though methods of delivery can. But what you say about tweaking is very true- which is why one of the meds I take is a former prescription med that costs pennies OTC. Its replacement costs tens of dollars, and Dr says is not as good as the original med. Ironically I am taking for it for a different purpose than it was originally developed for (though related), and cost is less than copay.

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